Reciprocal signalling by Notch–Collagen V–CALCR retains muscle stem cells in their niche
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منابع مشابه
Drug Resistance Driven by Cancer Stem Cells and Their Niche
Drug resistance represents one of the greatest challenges in cancer treatment. Cancer stem cells (CSCs), a subset of cells within the tumor with the potential for self-renewal, differentiation and tumorigenicity, are thought to be the major cause of cancer therapy failure due to their considerable chemo- and radioresistance, resulting in tumor recurrence and eventually metastasis. CSCs are situ...
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Stem cells within many tissues are thought to reside within a niche formed by a group of surrounding cells and their extracellular matrices, which provide an optimal microenvironment for the stem cells to function. In general, the niche is thought to consist of a highly organized microenvironment in which various factors, such as signals coming from secreted cytokines, extracellular matrix inte...
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The unique characteristics of stem cells, specifically pluripotency and self-renewal, are critical for sustaining the lifelong functionality of organs. Stem cells reside in a special microenvironment called the niche. Stem cells interact with the niche via adhesion molecules and exchange molecular signals that maintain the specific features of stem cells. A better understanding of the nature of...
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It is well known that new neurons are produced in the adult brain, in the hippocampus and in the subventricular zone. The neural progenitors formed in the subventricular zone migrate forward and join in neural circuits as interneurons in the olfactory bulb, the target for axons from the olfactory sensory neurons in the nose. These neurons are also continually replaced during adulthood from a st...
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Yukiko M. Yamashitaa and Tudorita Tumbarb aLife Sciences Institute, University of Michigan, Ann Arbor, Ann Arbor, MI 48109-2216; bDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853 Gage Crump (University of Southern California) presented evidence for a transfating of chondrocytes to the osteoblasts that rebuild bone during jawbone regeneration in zebrafish. Such ...
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ژورنال
عنوان ژورنال: Nature
سال: 2018
ISSN: 0028-0836,1476-4687
DOI: 10.1038/s41586-018-0144-9